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(2) Immunological and chemical barriers: Alveolar macrophages, proteolytic enzymes, and surfactants make up the majority of the immunological and chemical barriers found in the lungs

However, breakthroughs in identifying probable pathogenic pathways and molecular mechanisms associated with disease, born out of a consolidation of AMD pathologies, identified through observations of in vivo and ex vivo tissues, epidemiological studies, and in particular high-risk genes linked with AMD development, have been instrumental in the pursuit of animal models and potential therapies

Prkacin, I